期刊简介
《中国组织工程研究与临床康复》（原《中国临床康复》）杂志系卫生部主管，中国康复医学会、《中国组织工程研究与临床康复》杂志社主办的国家级学术期刊。经新出报刊[2006]288号批准，《中国临床康复》更名为《中国组织工程研究与临床康复》，变更后国内统一连续出版物号为CN 21-1539/R，ISSN 1673-8225，国内外公开发行，发行代号8-584，周刊，200页/期，A4开本。 更名后的《中国组织工程研究与临床康复》推出2009年的全新策划,年出版53期,各周刊征稿重点邀您参与,请您评估。网址：www.crter.org
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首页>中国组织工程研究杂志
- 杂志名称：中国组织工程研究杂志
- 主管单位：中华人民共和国卫生部
- 主办单位：中国康复医学会,《中国组织工程研究与临床康复》杂志社
- 国际刊号：2095-4344
- 国内刊号：21-1581/R
- 出版周期：周刊
期刊荣誉：百种中国杰出学术期刊期刊收录：维普收录(中), 北大核心期刊(中国人文社会科学核心期刊), 知网收录(中), 统计源核心期刊(中国科技论文核心期刊), 剑桥科学文摘, 万方收录(中)
合并全身放射损伤伤口表皮再上皮化延迟的机制研究
屈纪富；程天民；许霖水；史春梦；冉新泽
关键词：whole-body irradiation, re epithelization, wound healing, proliferation cell nuclear antigen (PCNA)
摘要：Objective To investigate the mechanisms of delayed re epithelization in wounds combined with whole body irradiation (WBI) injury.Methods We observed re epithelization in wounds by histological methods and transmission electron microscopy, detected the contents of proliferation cell nuclear antigen (PCNA) protein and mRNA using immunohistochemistry and in situ hybridization (ISH) methods. Results Re epithelization in wounds combined with WBI injury was significantly delayed as compared with simple incision injury, and the contents of PCNA protein and mRNA significantly decreased too. Conclusions WBI injury has direct effect on wound epidermic cells, especially the suppress of epidermic basal cell proliferation, which may be an important reason why wound combined with WBI injury heals more slowly.
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